Opportunity Information: Apply for RFA DA 25 034
Mechanistic Studies on Social Behavior in Substance Use Disorder (R01 Clinical Trials Not Allowed) is an NIH grant opportunity (RFA-DA-25-034) that supports mechanistic, transdisciplinary research aimed at explaining how social behavior relates to the onset, progression, and real-world consequences of substance use disorders (SUD) and common comorbidities. The central emphasis is on moving beyond descriptive findings toward clear, testable mechanisms, using integrated approaches that draw from social and cognitive neuroscience while also incorporating complementary disciplines that study social behavior from different angles. A key expected outcome is the development of a testable conceptual model or a computational model that can account for observed social behavior patterns and connect those patterns to SUD-relevant processes.
The NOFO is specifically focused on basic or translational work conducted in non-human animal models. Projects may involve generating new data in animal systems or conducting secondary analyses of existing animal-model datasets, as long as the work is designed to produce mechanistic insight and supports model-building that can be tested and refined. Studies that include human subjects are not allowed under this announcement; applications involving humans are expected to be submitted to one of the companion funding opportunities designed for human research.
This opportunity uses the NIH R01 mechanism (grant) and is categorized under Education and Health with CFDA number 93.279. The awarding agency is the National Institutes of Health. The posted award ceiling is $425,000. The original closing date listed for applications is 2024-08-14.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations (other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The NOFO also explicitly notes additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, Indian/Native American tribal governments other than federally recognized entities, and foreign (non-U.S.) organizations.
Overall, the grant is designed for research teams that can combine methods and theory across fields to explain social behavior in animal models in a way that meaningfully informs SUD science, with an emphasis on mechanistic explanations and model-driven, hypothesis-testable frameworks rather than purely observational or clinical-trial work.Apply for RFA DA 25 034
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Mechanistic Studies on Social Behavior in Substance Use Disorder (R01 Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2024-01-29.
- Applicants must submit their applications by 2024-08-14. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $425,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled Mechanistic Studies on Social Behavior in Substance Use Disorder (R01 Clinical Trials Not Allowed). The NIH funding opportunity number is RFA-DA-25-034.
Which agency is offering this funding opportunity?
The awarding agency is the National Institutes of Health (NIH).
What type of grant mechanism is used?
This opportunity uses the NIH R01 research project grant mechanism.
Are clinical trials allowed under this opportunity?
No. The announcement is explicitly designated as Clinical Trials Not Allowed.
What is the main scientific focus of this NOFO?
The NOFO supports mechanistic, transdisciplinary research that explains how social behavior relates to the onset, progression, and real-world consequences of substance use disorders (SUD) and common comorbidities. The emphasis is on moving beyond description to clear, testable mechanisms.
What does "mechanistic" mean in the context of this opportunity?
Within this NOFO, "mechanistic" means the research should aim to identify clear, testable explanations for observed relationships between social behavior and SUD-relevant processes, rather than only reporting associations or descriptive patterns.
What kinds of approaches are expected?
The NOFO highlights integrated approaches drawing from social and cognitive neuroscience, while also incorporating complementary disciplines that study social behavior from different perspectives. The intent is a combined, model-driven approach rather than a single-angle, purely observational study.
What is a key expected outcome for funded projects?
A key expected outcome is the development of a testable conceptual model or a computational model that can explain observed social behavior patterns and connect those patterns to SUD-relevant processes, with the expectation that the model can be tested and refined.
What research subjects are allowed (humans vs. animals)?
This NOFO is specifically focused on basic or translational work in non-human animal models. Studies that include human subjects are not allowed under this announcement.
If a project involves human subjects, can it be submitted to this NOFO?
No. Applications involving human subjects are not allowed for this NOFO. Human-subjects applications are expected to be submitted to companion funding opportunities designed for human research.
Does the NOFO allow secondary analysis instead of new data collection?
Yes. Projects may involve generating new data in animal systems or conducting secondary analyses of existing animal-model datasets, as long as the work is designed to produce mechanistic insight and supports model-building that can be tested and refined.
Is purely descriptive or observational research a good fit?
The central emphasis is on moving beyond descriptive findings toward clear, testable mechanisms and model-driven, hypothesis-testable frameworks. Projects framed as purely descriptive or observational are not aligned with the stated emphasis.
What topic areas does the opportunity connect to besides SUD?
In addition to substance use disorders, the NOFO references common comorbidities and aims to explain how social behavior relates to both SUD and those comorbid conditions in terms of onset, progression, and real-world consequences.
What is the posted award ceiling?
The posted award ceiling for this opportunity is $425,000.
What is the original application closing date listed?
The original closing date listed for applications is 2024-08-14.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA number 93.279.
How is this opportunity categorized?
This opportunity is categorized under Education and Health.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic and non-domestic organizations, including:
- State, county, and local governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Native American tribal organizations (other than federally recognized tribal governments)
- Public housing authorities/Indian housing authorities
- Nonprofits with or without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations (other than small businesses)
- Small businesses
- Foreign (non-U.S.) organizations
Are minority-serving institutions explicitly included in the eligible applicant types?
Yes. The NOFO explicitly notes eligibility for categories including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. The NOFO explicitly includes faith-based or community-based organizations among additional eligible applicant categories.
Are U.S. territories or possessions eligible to apply?
Yes. The NOFO explicitly notes eligibility for U.S. territories or possessions.
Are federal agencies eligible applicants?
Yes. The NOFO explicitly lists eligible federal agencies among the additional eligible applicant categories.
Are foreign (non-U.S.) organizations eligible?
Yes. The eligibility description explicitly includes foreign (non-U.S.) organizations.
What kind of research teams is this grant designed to support?
The grant is designed for teams that can combine methods and theory across fields to explain social behavior in animal models in a way that meaningfully informs SUD science, emphasizing mechanistic explanations and model-driven, hypothesis-testable frameworks.
What is the overall "fit" of a strong application under this NOFO?
Based on the description provided, a strong fit is a project in non-human animal models that uses integrated, transdisciplinary approaches to produce mechanistic insight into social behavior as it relates to SUD and comorbidities, and that culminates in a testable conceptual or computational model connecting social behavior patterns to SUD-relevant processes.
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