Opportunity Information: Apply for RFA AA 18 007
The NIH Blueprint for Neuroscience Research funding opportunity titled "Dynamic Neuroimmune Interactions in the Transition from Normal CNS Function to Disorders (R01)" (Funding Opportunity Number RFA-AA-18-007) is a discretionary NIH grant solicitation that uses the R01 research project grant mechanism. It is aimed at supporting research that advances understanding of how neuroimmune interactions change over time, specifically how dynamic signaling and relationships between the nervous system and immune system may shift from supporting normal central nervous system (CNS) function to contributing to or driving CNS disorders. In practical terms, the opportunity is positioned for projects that focus on mechanisms and trajectories of change rather than static snapshots, emphasizing transitions that could illuminate disease onset, progression, or points where interventions might prevent or reverse harmful outcomes. The NIH Blueprint framing also signals that the topic is intended to be broadly relevant across neuroscience, potentially spanning multiple disorders or biological contexts and encouraging research that can inform the field beyond a single narrow condition.
The application deadline for this announcement is fixed and strict: all eligible non-AIDS applications are due on December 7, 2017, by 5:00 PM local time of the applicant organization. The notice makes it explicit that late applications will not be accepted, which is consistent with NIH policy for many Requests for Applications (RFAs) that operate on single or limited receipt dates. Applicants are urged to submit early so there is enough time to address any submission errors identified by the electronic systems before the deadline, since corrections often require resubmission and can be blocked by last-minute technical or validation issues.
In terms of funding parameters, the listed award ceiling is $400,000, which sets an upper bound on the amount available per award under this announcement as presented in the source data. While the entry does not specify the number of expected awards in the provided text, it does indicate that NIH is the sponsoring agency and that the instrument type is a grant. The activity category spans a broad set of public mission areas (education, environment, health, income security, and social services), but the scientific theme and the administering agency clearly place this opportunity primarily in the biomedical and neuroscience research domain.
Eligibility is unusually broad and explicitly inclusive of many organization types. Standard eligible applicants include a wide range of U.S.-based entities such as state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with 501(c)(3) status (and nonprofits without 501(c)(3) status) that are not institutions of higher education; for-profit organizations (other than small businesses) and small businesses; and an "other" category that can capture additional eligible organization structures consistent with NIH rules.
The announcement also highlights additional eligible applicant categories to emphasize inclusivity and participation across institution types and communities. These specifically include Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; regional organizations; eligible federal government agencies; Indian/Native American Tribal Governments that are not federally recognized; and U.S. territories or possessions. Importantly, the solicitation is open to non-U.S. applicants as well: non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are eligible to apply. It also allows non-domestic components of U.S. organizations, and it permits foreign components as defined by the NIH Grants Policy Statement. This matters for research areas like neuroimmune interactions where specialized cohorts, unique biological resources, or particular expertise may reside outside the United States, and it signals that NIH is open to international collaboration or leadership when scientifically justified.
The source data also lists multiple CFDA numbers (93.113, 93.121, 93.213, 93.242, 93.273, 93.279, 93.286, 93.350, 93.361, 93.853, 93.865, 93.866, 93.867), reflecting the NIH’s multi-institute structure and the way different NIH programs map to cataloged federal assistance listings. The opportunity record shows a creation date of August 23, 2017, with an original closing date of December 7, 2017, aligning with the stated single due date. Overall, this R01 opportunity is best read as a targeted NIH neuroscience initiative intended to fund rigorous, mechanistic, and time-sensitive research on how immune and nervous system interactions evolve from normal physiology into pathological states, with a firm submission deadline and broad domestic and international eligibility.Apply for RFA AA 18 007
- The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "NIH Blueprint for Neuroscience Research: Dynamic Neuroimmune Interactions in the Transition from Normal CNS Function to Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.213, 93.242, 93.273, 93.279, 93.286, 93.350, 93.361, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2017-08-23.
- Applicants must submit their applications by 2017-12-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Dynamic Neuroimmune Interactions in the Transition from Normal CNS Function to Disorders (R01)
What is the official title of this funding opportunity?
The opportunity is titled "Dynamic Neuroimmune Interactions in the Transition from Normal CNS Function to Disorders (R01)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-AA-18-007.
Which federal agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH), under the NIH Blueprint for Neuroscience Research framing.
What type of funding mechanism is being used?
This solicitation uses the R01 research project grant mechanism.
Is this opportunity a grant or a contract?
It is a grant opportunity (instrument type: grant).
What is the main scientific focus of the announcement?
The focus is on neuroimmune interactions and how they change over time, especially how signaling and relationships between the nervous system and immune system may shift from supporting normal central nervous system (CNS) function to contributing to or driving CNS disorders.
What does "dynamic" mean in the context of this opportunity?
Based on the description provided, "dynamic" emphasizes mechanisms and trajectories of change over time rather than static snapshots. The intent is to study transitions that may illuminate disease onset, progression, or points where interventions could prevent or reverse harmful outcomes.
Is the opportunity limited to one disorder or condition?
The NIH Blueprint framing signals the topic is intended to be broadly relevant across neuroscience and may span multiple disorders or biological contexts, rather than being limited to a single narrow condition.
What is the application deadline?
All eligible non-AIDS applications are due on December 7, 2017, by 5:00 PM local time of the applicant organization.
Is the deadline flexible or can late applications be accepted?
No. The announcement explicitly states that late applications will not be accepted.
What time zone applies to the deadline time?
The deadline is 5:00 PM local time of the applicant organization.
Does the opportunity encourage early submission?
Yes. Applicants are urged to submit early to allow time to address electronic submission errors that may require correction and resubmission before the deadline.
What is the maximum award amount listed for this opportunity?
The listed award ceiling is $400,000.
Does the provided information state how many awards NIH expects to make?
No. The provided information does not specify the number of expected awards.
When was this opportunity record created?
The opportunity record shows a creation date of August 23, 2017.
What is the original closing date shown in the record?
The record shows an original closing date of December 7, 2017, matching the stated due date.
What types of U.S. organizations are eligible to apply?
Eligibility is broad and includes (as listed): state governments; county governments; city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with 501(c)(3) status; nonprofits without 501(c)(3) status that are not institutions of higher education; for-profit organizations (other than small businesses); and small businesses.
Are community-based or faith-based organizations eligible?
Yes. The announcement explicitly includes faith-based or community-based organizations as eligible applicant categories.
Are minority-serving institutions (MSIs) explicitly included as eligible applicants?
Yes. The announcement specifically includes Alaska Native and Native Hawaiian Serving Institutions; AANAPISIs (Asian American, Native American, and Pacific Islander Serving Institutions); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); and Tribally Controlled Colleges and Universities (TCCUs).
Are tribal governments that are not federally recognized eligible?
Yes. The eligibility list includes Indian/Native American Tribal Governments that are not federally recognized.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are explicitly listed as eligible.
Are federal government agencies eligible to apply?
Yes. The announcement includes eligible federal government agencies among the additional eligible applicant categories.
Can non-U.S. (foreign) organizations apply as the applicant?
Yes. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are eligible to apply.
Can a U.S. organization include non-U.S. components?
Yes. The opportunity allows non-domestic components of U.S. organizations.
Are foreign components allowed under this solicitation?
Yes. The solicitation permits foreign components as defined by the NIH Grants Policy Statement.
Why does the announcement emphasize international eligibility?
Based on the provided description, this emphasis matters for research areas like neuroimmune interactions where specialized cohorts, unique biological resources, or particular expertise may be located outside the United States, and it signals openness to international collaboration or leadership when scientifically justified.
What public mission areas are associated with the activity category in the record?
The activity category spans education, environment, health, income security, and social services, though the scientific theme and administering agency indicate the opportunity primarily sits in biomedical and neuroscience research.
Which CFDA numbers are associated with this opportunity?
The source data lists these CFDA numbers: 93.113, 93.121, 93.213, 93.242, 93.273, 93.279, 93.286, 93.350, 93.361, 93.853, 93.865, 93.866, 93.867.
What do the multiple CFDA numbers indicate?
They reflect NIH's multi-institute structure and how different NIH programs map to cataloged federal assistance listings.
What is the key takeaway for prospective applicants?
This is a targeted NIH R01 opportunity to fund rigorous, mechanistic, time-sensitive research on how immune and nervous system interactions evolve from normal physiology into pathological states, with a firm submission deadline and broad eligibility across domestic and international organizations.
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