Opportunity Information: Apply for RFA AA 18 007
The NIH Blueprint for Neuroscience Research funding opportunity titled "Dynamic Neuroimmune Interactions in the Transition from Normal CNS Function to Disorders (R01)" (Funding Opportunity Number RFA-AA-18-007) is a discretionary NIH grant solicitation that uses the R01 research project grant mechanism. It is aimed at supporting research that advances understanding of how neuroimmune interactions change over time, specifically how dynamic signaling and relationships between the nervous system and immune system may shift from supporting normal central nervous system (CNS) function to contributing to or driving CNS disorders. In practical terms, the opportunity is positioned for projects that focus on mechanisms and trajectories of change rather than static snapshots, emphasizing transitions that could illuminate disease onset, progression, or points where interventions might prevent or reverse harmful outcomes. The NIH Blueprint framing also signals that the topic is intended to be broadly relevant across neuroscience, potentially spanning multiple disorders or biological contexts and encouraging research that can inform the field beyond a single narrow condition.
The application deadline for this announcement is fixed and strict: all eligible non-AIDS applications are due on December 7, 2017, by 5:00 PM local time of the applicant organization. The notice makes it explicit that late applications will not be accepted, which is consistent with NIH policy for many Requests for Applications (RFAs) that operate on single or limited receipt dates. Applicants are urged to submit early so there is enough time to address any submission errors identified by the electronic systems before the deadline, since corrections often require resubmission and can be blocked by last-minute technical or validation issues.
In terms of funding parameters, the listed award ceiling is $400,000, which sets an upper bound on the amount available per award under this announcement as presented in the source data. While the entry does not specify the number of expected awards in the provided text, it does indicate that NIH is the sponsoring agency and that the instrument type is a grant. The activity category spans a broad set of public mission areas (education, environment, health, income security, and social services), but the scientific theme and the administering agency clearly place this opportunity primarily in the biomedical and neuroscience research domain.
Eligibility is unusually broad and explicitly inclusive of many organization types. Standard eligible applicants include a wide range of U.S.-based entities such as state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with 501(c)(3) status (and nonprofits without 501(c)(3) status) that are not institutions of higher education; for-profit organizations (other than small businesses) and small businesses; and an "other" category that can capture additional eligible organization structures consistent with NIH rules.
The announcement also highlights additional eligible applicant categories to emphasize inclusivity and participation across institution types and communities. These specifically include Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; regional organizations; eligible federal government agencies; Indian/Native American Tribal Governments that are not federally recognized; and U.S. territories or possessions. Importantly, the solicitation is open to non-U.S. applicants as well: non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are eligible to apply. It also allows non-domestic components of U.S. organizations, and it permits foreign components as defined by the NIH Grants Policy Statement. This matters for research areas like neuroimmune interactions where specialized cohorts, unique biological resources, or particular expertise may reside outside the United States, and it signals that NIH is open to international collaboration or leadership when scientifically justified.
The source data also lists multiple CFDA numbers (93.113, 93.121, 93.213, 93.242, 93.273, 93.279, 93.286, 93.350, 93.361, 93.853, 93.865, 93.866, 93.867), reflecting the NIH’s multi-institute structure and the way different NIH programs map to cataloged federal assistance listings. The opportunity record shows a creation date of August 23, 2017, with an original closing date of December 7, 2017, aligning with the stated single due date. Overall, this R01 opportunity is best read as a targeted NIH neuroscience initiative intended to fund rigorous, mechanistic, and time-sensitive research on how immune and nervous system interactions evolve from normal physiology into pathological states, with a firm submission deadline and broad domestic and international eligibility.Apply for RFA AA 18 007
- The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "NIH Blueprint for Neuroscience Research: Dynamic Neuroimmune Interactions in the Transition from Normal CNS Function to Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.213, 93.242, 93.273, 93.279, 93.286, 93.350, 93.361, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2017-08-23.
- Applicants must submit their applications by 2017-12-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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