RePORT International Coordinating Center (RICC) (U01 Clinical Trial Not Allowed) | RFA AI 21 078

Opportunity Information: Apply for RFA AI 21 078

The RePORT International Coordinating Center (RICC) funding opportunity (RFA AI 21 078) is a National Institutes of Health (NIH) cooperative agreement (U01) focused on supporting a single, centralized coordinating center for the global Regional Prospective Observational Research in Tuberculosis (RePORT) networks. The overall goal is to strengthen and align tuberculosis (TB) and TB/HIV observational research across multiple regions by providing coordination, shared infrastructure, and consistent operational support. In practical terms, the RICC is meant to function as the hub that helps the various RePORT network sites work together more efficiently, produce higher-quality data, and accelerate progress in TB and TB/HIV science through better collaboration and harmonization. The FOA explicitly indicates "Clinical Trial Not Allowed," signaling that the work supported under this award should be centered on observational research coordination and related enabling activities rather than interventional clinical trials.

The mission of the global RePORT networks, which the RICC is expected to advance, includes improving regional and international TB and TB/HIV research, building sustainable research capacity, strengthening infrastructure, and fostering collaboration among partners. The coordinating center is therefore positioned as both a scientific and operational enabler: it is expected to coordinate planning and implementation of research activities across the networks and to establish and maintain the core infrastructure required to carry out those activities. This infrastructure emphasis typically implies cross-network systems and processes that allow sites to collect, manage, share, and analyze observational data in consistent ways, along with mechanisms for communication, governance support, and coordination of multi-site scientific efforts.

Because this is a cooperative agreement, the NIH will generally have substantial programmatic involvement compared with a traditional grant mechanism. In a U01 structure, awardees often work closely with NIH staff on key aspects of project direction, coordination priorities, and performance expectations, reflecting the collaborative nature of a network-wide coordinating center. The activity category is Health, and the listed CFDA number is 93.855, placing it within NIH's broader health research support portfolio.

Eligibility is broad and includes a wide range of domestic and international organizations. Eligible applicants listed in the source include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized governments; public housing authorities/Indian housing authorities; nonprofit organizations with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other entities. The FOA also calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, non-domestic (non-U.S.) entities (foreign organizations), regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions. This wide eligibility reflects the global and collaborative nature of TB research and the need for coordination that can span different institutional types and geographies.

Key administrative details from the listing include the opportunity category being discretionary, the funding instrument being a cooperative agreement, and the agency being NIH. The opportunity was created on 2021-11-02, and the original closing date is listed as 2022-03-17. The award ceiling and expected number of awards are not specified in the provided source data, which commonly means applicants would need to consult the full FOA text (or related NIH budget guidance) to understand anticipated budget ranges, allowable costs, and the scale of the coordinating center activities NIH intends to support.

Overall, this opportunity is designed to fund a coordinating center that can provide the backbone for multi-country, multi-site observational TB and TB/HIV research efforts. Rather than funding a single research study in isolation, it focuses on enabling and organizing research across the entire RePORT network ecosystem by standardizing approaches, supporting shared infrastructure, and improving collaboration so that regional and international partners can generate more comparable, higher-impact scientific outputs.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "RePORT International Coordinating Center (RICC) (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
• This funding opportunity was created on 2021-11-02.
• Applicants must submit their applications by 2022-03-17. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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