Opportunity Information: Apply for PA 17 120
Discovering Novel Targets: The Molecular Genetics of Drug Addiction and Related Co-Morbidities (R01) is an NIH research grant opportunity (Funding Opportunity Number PA-17-120; CFDA 93.279) that supports hypothesis-driven, investigator-initiated projects aimed at uncovering the genetic and molecular factors that contribute to substance use disorders and closely related co-morbid conditions. The main goal is to identify, confirm, and functionally characterize genetic loci, variants, and haplotypes that influence vulnerability to addiction. A major emphasis is placed on results that can move beyond statistical association and help explain biological mechanisms, including findings that could point to new therapeutic targets or help predict who is more likely to respond to specific treatments.
A key priority within this FOA is research that uses intermediate phenotypes (often called endophenotypes) to connect genetic variation to addiction-related outcomes. Rather than focusing only on diagnostic categories, applicants are encouraged to study measurable traits that sit between genes and clinical disease, such as neurobiological markers, behavioral phenotypes, cognitive measures, stress reactivity, impulsivity, reward sensitivity, or other quantifiable features that may clarify how genetic risk translates into addiction vulnerability or co-occurring disorders. Projects can also examine how these intermediate phenotypes relate to the onset, course, severity, relapse risk, or treatment response in drug addiction, as well as how they intersect with psychiatric, behavioral, or medical co-morbidities.
The FOA strongly encourages the use of modern genetic, genomic, and computational strategies, including large-scale analyses and approaches that integrate multiple data sources. Appropriate study designs and methods may include linkage studies, linkage disequilibrium mapping, case-control studies, and family-based studies, along with genome-wide or other high-throughput genomic approaches. The announcement also highlights the value of computational and integrative work, including combining new study data with existing repositories and databases to strengthen discovery, replication, and interpretation. This includes analyses that supplement substance abuse genetics and genomics resources with information drawn from other relevant datasets, enabling broader or more powerful evaluations of genetic risk architecture.
In terms of data sources and populations, the FOA is deliberately broad. Investigators may collect or analyze data from the general population, special populations, and recent admixed populations, as well as from animal models. Importantly, the opportunity explicitly allows and supports secondary data analysis, meaning researchers can propose rigorous new analyses of already-collected human or animal datasets when the work is well-justified and likely to produce meaningful insights. This flexibility makes the FOA suitable for both primary data collection projects and projects focused on reanalysis, harmonization, and integration of existing genomic and phenotypic resources.
The scientific scope extends beyond simple gene discovery by encouraging applicants to incorporate functional and interaction-focused elements when appropriate. This includes functional characterization to test how specific variants influence gene expression or biological pathways, studies of gene-by-gene interactions, gene-by-environment interactions, and more complex gene-by-environment-by-development frameworks that recognize how genetic effects can differ across life stages or developmental windows. Pharmacogenetics is also encouraged, reflecting interest in understanding how genetic differences influence medication response, treatment outcomes, adverse effects, or personalized intervention strategies. The FOA also welcomes the inclusion of non-human models as part of a broader translational approach, particularly when they help validate candidate genes, probe mechanisms, or test causal hypotheses that are difficult to examine in humans alone.
Eligibility is broad and includes a wide range of U.S. and non-U.S. applicant organizations, reflecting NIH-wide policies for R01 mechanisms. Eligible applicants include federal, state, county, and local governments; public and private institutions of higher education; independent school districts; special district governments; tribal governments (including federally recognized) and tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; and other types of organizations. The FOA specifically notes additional eligible categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations and regional organizations. Foreign organizations and foreign institutions are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined in the NIH Grants Policy Statement) are allowed, making it open to international collaborations where scientifically justified.
From an administrative standpoint, this is a discretionary NIH grant using the R01 funding instrument within the education and health funding activity category. The original closing date listed in the source data is January 7, 2020, and the record creation date is January 10, 2017. An award ceiling is not specified in the provided listing, which is common for many NIH R01 opportunities where budgets depend on project scope and NIH policy rather than a single fixed cap. Overall, the FOA is designed to push the field toward biologically grounded, analytically rigorous discoveries in addiction genetics that can help explain risk, illuminate mechanisms, and ultimately support improved prevention and treatment strategies for addiction and its related co-morbidities.Apply for PA 17 120
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Discovering Novel Targets: The Molecular Genetics of Drug Addiction and Related Co-Morbidities (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2017-01-10.
- Applicants must submit their applications by 2020-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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