Opportunity Information: Apply for RFA MH 17 360
The grant opportunity titled "Improving the HIV Pre-Exposure Prophylaxis (PrEP) Cascade (R01)" (Funding Opportunity Number: RFA-MH-17-360) is a National Institutes of Health (NIH) discretionary funding announcement that supports Research Project Grants (R01). Its central purpose is to strengthen the HIV oral pre-exposure prophylaxis (PrEP) care continuum, often described as the PrEP "cascade," by funding research that designs, develops, and tests interventions aimed at improving how people at substantial risk for HIV move through PrEP care over time. In practical terms, the FOA is focused on real-world strategies that help individuals start PrEP, stay connected to PrEP-related care, and maintain effective use of PrEP as clinically appropriate.
A key emphasis of this FOA is improving PrEP care engagement and retention. This includes interventions that help people initiate and consistently participate in ongoing PrEP services such as regular follow-up visits, laboratory monitoring, counseling, and other supports that are part of routine PrEP care. The announcement also calls for interventions that directly support medication adherence and persistence, meaning consistent and correct use of PrEP over time, and continued use for as long as the person remains at meaningful risk for HIV. The language of the FOA indicates a strong interest in interventions that address drop-off points across the PrEP cascade, where individuals may discontinue care, have difficulty staying on medication, or lose access to ongoing support.
The activity categories for this opportunity fall under education and health, and the associated CFDA numbers listed are 93.242, 93.279, 93.361, 93.855, 93.856. While the FOA title centers on HIV prevention, the grant mechanism and NIH context suggest a broad, interdisciplinary approach that can include clinical, behavioral, implementation science, and health services research methods, as long as the proposed work is aimed at measurable improvements in engagement, retention, adherence, and persistence within oral PrEP delivery.
Eligibility is broad and intentionally inclusive of many organizational types. Standard eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; and a range of nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education institutions where specified). The FOA also allows for-profit organizations (other than small businesses) and small businesses, as well as other entities that meet NIH eligibility requirements.
In addition to the general categories above, the FOA explicitly highlights other eligible applicant types that NIH encourages to apply, reflecting an interest in reaching populations most affected by HIV and organizations embedded in communities where PrEP uptake and continuity may be challenging. These include Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Indian/Native American Tribal Governments that are not federally recognized; faith-based or community-based organizations; eligible agencies of the federal government; regional organizations; U.S. territories or possessions; and non-domestic (non-U.S.) entities (foreign organizations). This explicit inclusivity signals that NIH is open to diverse geographic settings and organizational structures, including community-rooted institutions and international partners, when they can meaningfully contribute to strengthening the PrEP care continuum.
From an administrative standpoint, the opportunity was created on 2016-09-22, with an original closing date of 2017-01-06. The funding instrument type is a grant, using the R01 research project mechanism, which typically supports hypothesis-driven or intervention-testing research of meaningful scope. The source data provided does not specify an award ceiling or the expected number of awards, which means applicants would ordinarily need to consult the full FOA text and NIH budget guidance to understand typical budget limits, project period expectations, and any institute-specific constraints.
Overall, this FOA is aimed at moving beyond simply making PrEP available and instead improving the systems, behaviors, and supports that determine whether oral PrEP is started, used correctly, and sustained over time among people at substantial risk for HIV infection. The emphasis on engagement, retention, adherence, and persistence reflects a practical prevention priority: improving outcomes across the full PrEP cascade so that PrEP can deliver its real-world protective benefit at the population level.Apply for RFA MH 17 360
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Improving the HIV Pre-Exposure Prophylaxis (PrEP) Cascade (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.279, 93.361, 93.855, 93.856.
- This funding opportunity was created on 2016-09-22.
- Applicants must submit their applications by 2017-01-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Improving the HIV Pre-Exposure Prophylaxis (PrEP) Cascade (R01)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-MH-17-360.
Which federal agency is offering this opportunity?
This is a National Institutes of Health (NIH) discretionary funding announcement.
What type of funding mechanism does this opportunity use?
The funding instrument is a grant, and the activity mechanism is a Research Project Grant (R01).
What is the main purpose of this FOA?
The central purpose is to strengthen the HIV oral pre-exposure prophylaxis (PrEP) care continuum (the PrEP "cascade") by supporting research that designs, develops, and tests interventions that improve how people at substantial risk for HIV move through PrEP care over time.
What does the FOA mean by the PrEP "cascade"?
In this announcement, the PrEP cascade refers to the continuum of PrEP care over time, including starting PrEP, staying connected to PrEP-related services, and maintaining effective use as clinically appropriate. It also includes points where people may drop off from care or discontinue medication.
What kinds of outcomes or improvements is NIH trying to achieve through this FOA?
The FOA emphasizes measurable improvements in PrEP care engagement and retention, along with medication adherence and persistence, so that individuals can start PrEP, remain in PrEP-related care, and use PrEP consistently for as long as they remain at meaningful risk for HIV.
What aspects of PrEP care engagement and retention are specifically highlighted?
The FOA highlights interventions that help people initiate and consistently participate in ongoing PrEP services such as follow-up visits, laboratory monitoring, counseling, and other supports that are part of routine PrEP care.
Does this FOA focus on medication-taking behavior?
Yes. It calls for interventions that directly support medication adherence (consistent and correct use) and persistence (continued use over time, as long as clinically appropriate and risk remains meaningful).
Is the FOA interested in addressing drop-off points in PrEP care?
Yes. The language indicates strong interest in interventions that address drop-off points across the PrEP cascade, such as discontinuation of care, difficulty staying on medication, or loss of access to ongoing support.
What research approaches are appropriate for this R01?
The NIH context and R01 mechanism suggest an interdisciplinary approach may be appropriate, including clinical, behavioral, implementation science, and health services research methods, as long as the work is aimed at improving engagement, retention, adherence, and persistence within oral PrEP delivery.
Which activity categories are associated with this opportunity?
The activity categories listed are education and health.
What CFDA numbers are associated with this FOA?
The associated CFDA numbers listed are 93.242, 93.279, 93.361, 93.855, 93.856.
Who is eligible to apply?
Eligibility is broad and includes (among others): state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; nonprofit organizations (501(c)(3) and non-501(c)(3), excluding higher education institutions where specified); for-profit organizations (other than small businesses); small businesses; and other entities that meet NIH eligibility requirements.
Are community-based and faith-based organizations eligible?
Yes. The FOA explicitly lists faith-based or community-based organizations among the eligible applicant types NIH encourages to apply.
Are minority-serving institutions specifically encouraged to apply?
Yes. The FOA explicitly highlights and encourages applications from several types of minority-serving institutions, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISISs, Hispanic-serving Institutions, HBCUs, and TCCUs.
Are tribal governments eligible?
Yes. Eligibility includes federally recognized Native American tribal governments, and the FOA also highlights Indian/Native American Tribal Governments that are not federally recognized as encouraged applicant types.
Are U.S. territories or possessions eligible?
Yes. The FOA explicitly lists U.S. territories or possessions among the eligible applicant types it highlights.
Are non-U.S. (foreign) organizations allowed to apply?
Yes. The FOA explicitly includes non-domestic (non-U.S.) entities (foreign organizations) among the highlighted eligible applicant types.
Are federal government agencies eligible to apply?
Yes. The FOA highlights eligible agencies of the federal government among encouraged applicant types.
Does the FOA mention whether regional organizations can apply?
Yes. Regional organizations are explicitly listed among the eligible applicant types NIH encourages to apply.
When was this opportunity created?
The opportunity was created on 2016-09-22.
What was the original closing date?
The original closing date was 2017-01-06.
Does the provided information specify an award ceiling or number of awards?
No. The source information provided does not specify an award ceiling or the expected number of awards.
What does the R01 mechanism imply about the scope of work?
Based on the description provided, the R01 research project mechanism typically supports hypothesis-driven or intervention-testing research of meaningful scope.
Is the FOA focused on oral PrEP specifically?
Yes. The FOA is focused on strengthening the care continuum for HIV oral pre-exposure prophylaxis (PrEP).
What is the overall practical goal of this FOA?
The overall goal is to move beyond simply making PrEP available and improve the systems, behaviors, and supports that determine whether oral PrEP is started, used correctly, and sustained over time, improving real-world preventive benefit at the population level.
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