Opportunity Information: Apply for PAR 25 238
The National Library of Medicine (NLM), part of the National Institutes of Health (NIH), is offering an R01 grant opportunity titled "NLM Research Grants in Biomedical Informatics and Data Science (R01 Clinical Trial Optional)" (Funding Opportunity Number PAR-25-238). The program is aimed at supporting innovative research and development in biomedical informatics and data science, with a strong emphasis on approaches that advance biomedical discovery and data-powered health. Projects are expected to bring together complex, interconnected streams of research outputs and turn them into outcomes that matter in real settings, such as new scientific insights, improved clinical care, stronger public health practices, and tools or knowledge that can support personal wellness.
A central theme of the opportunity is building work that is scalable, reproducible, and generalizable. In practice, that means NLM is looking for methods, systems, and frameworks that can handle real-world complexity (large, messy, multi-source data and digital artifacts), can be reliably re-run and validated by other teams, and can transfer across problems, institutions, and populations rather than being overly tailored to one dataset or one site. The scope is intentionally broad across biomedical informatics and data science, but the emphasis is on new and innovative methods that enable data-driven discovery in biomedical and clinical health sciences. NLM also highlights interest in domain-independent approaches, meaning tools and methods that can be reused across different biomedical areas, and that support the full lifecycle of data and digital objects: discovery, curation, analysis, organization, and management. This includes not only analytic techniques, but also the infrastructure and practices that make data and digital resources findable, usable, and integrable at scale.
The funding instrument is a discretionary grant using the NIH R01 mechanism, and clinical trials are optional under this announcement. The activity category is listed under Education and Health, and the CFDA number associated with the opportunity is 93.879. The opportunity includes a listed award ceiling of $250,000. The original closing date provided is January 7, 2026, and the opportunity record shows a creation date of November 25, 2024.
Eligibility is broad and includes many types of U.S. and non-U.S. applicants. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (in both cases, other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities. The announcement also explicitly calls out additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal government agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). Overall, this opportunity is designed for teams proposing forward-looking biomedical informatics or data science research with clear pathways to broad impact and reuse, rather than narrow, one-off solutions.Apply for PAR 25 238
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "NLM Research Grants in Biomedical Informatics and Data Science (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.879.
- This funding opportunity was created on 2024-11-25.
- Applicants must submit their applications by 2026-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is an NIH R01 grant opportunity from the National Library of Medicine (NLM) titled "NLM Research Grants in Biomedical Informatics and Data Science (R01 Clinical Trial Optional)." The Funding Opportunity Number (FON) is PAR-25-238.
Which agency is offering the grant?
The grant is offered by the National Library of Medicine (NLM), which is part of the National Institutes of Health (NIH).
What is the purpose of this program?
The program supports innovative research and development in biomedical informatics and data science, with an emphasis on approaches that advance biomedical discovery and data-powered health. Projects are expected to translate complex, interconnected research outputs into outcomes that matter in real-world settings.
What kinds of real-world outcomes does NLM emphasize?
The description highlights outcomes such as new scientific insights, improved clinical care, stronger public health practices, and tools or knowledge that can support personal wellness.
What research areas are in scope?
The scope is intentionally broad across biomedical informatics and data science, but it emphasizes new and innovative methods that enable data-driven discovery in biomedical and clinical health sciences.
What does NLM mean by “scalable, reproducible, and generalizable” research?
NLM is looking for methods, systems, and frameworks that can handle real-world complexity (including large, messy, multi-source data and digital artifacts), can be reliably re-run and validated by other teams, and can transfer across problems, institutions, and populations rather than being narrowly tailored to one dataset or one site.
Does this opportunity focus on methods only, or also on infrastructure and data practices?
It includes analytic techniques as well as infrastructure and practices that make data and digital resources findable, usable, and integrable at scale.
What does “domain-independent approaches” mean in this announcement?
It refers to tools and methods that can be reused across different biomedical areas, rather than approaches limited to a single domain or specialty.
Which parts of the data and digital object lifecycle are relevant?
The announcement references support for the full lifecycle of data and digital objects, including discovery, curation, analysis, organization, and management.
What is the grant mechanism and funding instrument?
The opportunity uses the NIH R01 mechanism and is listed as a discretionary grant.
Are clinical trials allowed under this funding opportunity?
Yes. Clinical trials are optional under this announcement.
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PAR-25-238.
What is the CFDA number associated with this opportunity?
The CFDA number listed for this opportunity is 93.879.
What activity category is associated with this opportunity?
The activity category is listed under Education and Health.
What is the award ceiling listed for this opportunity?
The opportunity includes a listed award ceiling of $250,000.
When is the closing date?
The original closing date provided is January 7, 2026.
When was the opportunity record created?
The opportunity record shows a creation date of November 25, 2024.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. and non-U.S. applicants. Eligible entities include government organizations, academic institutions, nonprofits, for-profits (other than small businesses), small businesses, and other eligible entities listed in the announcement.
Are U.S. state and local governments eligible?
Yes. State governments, county governments, and city or township governments are listed as eligible applicants.
Are special district governments eligible?
Yes. Special district governments are listed as eligible applicants.
Are public and private universities eligible?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education are listed as eligible applicants.
Are independent school districts eligible?
Yes. Independent school districts are listed as eligible applicants.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments are eligible, and tribal organizations other than federally recognized tribal governments are also listed as eligible.
Are nonprofits eligible?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status are eligible (in both cases, other than institutions of higher education).
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are eligible, and small businesses are also listed as eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly called out as eligible.
Are non-U.S. (foreign) organizations eligible?
Yes. Non-domestic (non-U.S.) entities (foreign organizations) are explicitly included as eligible applicants.
Are minority-serving institutions specifically encouraged or eligible?
The announcement explicitly calls out multiple institution types as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly called out as eligible.
Are federal agencies eligible to apply?
Yes. Eligible federal government agencies are explicitly included in the list of eligible applicants.
What kinds of projects seem to fit best based on the description?
Projects proposing forward-looking biomedical informatics or data science research with clear pathways to broad impact and reuse are emphasized, particularly work that is scalable, reproducible, generalizable, and not narrowly designed as a one-off solution for a single dataset or site.
Does the announcement prefer narrow, single-site solutions?
No. The description emphasizes approaches that transfer across problems, institutions, and populations rather than being overly tailored to one dataset or one site.
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|---|
| The Role of Work in Health Disparities in the U.S. (R01 Clinical Trials Optional) Apply for PAR 25 292 Funding Number: PAR 25 292 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Continuing Umbrella of Research Experiences (CURE) Non-Mentored Research Scientist Career Development Award (K22 Clinical Trial Required) Apply for PAR 24 318 Funding Number: PAR 24 318 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Continuing Umbrella of Research Experiences (CURE) Non-Mentored Research Scientist Career Development Award (K22 Independent Clinical Trial Not Allowed) Apply for PAR 24 317 Funding Number: PAR 24 317 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Continuing Umbrella of Research Experiences (CURE) Mentored Clinical Scientist Research Career Development Award (K08 Clinical Trial Required) Apply for PAR 24 319 Funding Number: PAR 24 319 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Continuing Umbrella of Research Experiences (CURE) Mentored Clinical Scientist Research Career Development Award (K08 Clinical Trial Not Allowed) Apply for PAR 24 320 Funding Number: PAR 24 320 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Research to Address Systemic and Structural Barriers and Facilitators to Improve the HIV Pre-Exposure Prophylaxis (PrEP) Care Continuum for People Who Use Substances (R34 Clinical Trials Required) Apply for RFA DA 26 004 Funding Number: RFA DA 26 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: $225,000 |
| Research to Address Systemic and Structural Barriers and Facilitators to Improve the HIV Pre-Exposure Prophylaxis (PrEP) Care Continuum for People Who Use Substances (R01 Clinical Trials Required) Apply for RFA DA 26 003 Funding Number: RFA DA 26 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Interventions to Address Disparities in Liver Diseases and Liver Cancer (R01 - Clinical Trials Optional) Apply for PAR 25 299 Funding Number: PAR 25 299 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed) Apply for RFA DA 26 056 Funding Number: RFA DA 26 056 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed) Apply for RFA DA 26 055 Funding Number: RFA DA 26 055 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional) Apply for PAR 25 100 Funding Number: PAR 25 100 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Interventions to Reduce Sleep Health Disparities (R01 - Clinical Trials Optional) Apply for PAR 24 330 Funding Number: PAR 24 330 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Informatics Tools for the Pangenome (U01 Clinical Trial Not Allowed) Apply for RFA HG 25 007 Funding Number: RFA HG 25 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Optional) Apply for PAR 25 321 Funding Number: PAR 25 321 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Not Allowed) Apply for PAR 25 346 Funding Number: PAR 25 346 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Model Continuums of Care Initiative (MCCI) to Advance Health Equity and End Health Disparities Among Women and Girls in Racial/Ethnic Minority and Other Underserved Communities (U34 Clinical Trials Required) Apply for RFA AA 24 012 Funding Number: RFA AA 24 012 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional) Apply for PAR 25 317 Funding Number: PAR 25 317 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Integrating Biospecimen Science Approaches into Clinical Assay Development (U01 Clinical Trial Not Allowed) Apply for PAR 25 325 Funding Number: PAR 25 325 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| D-START: Data Science Track Award for Research Transition (D/START) (R03-Clinical Trial Optional) Apply for PAS 25 236 Funding Number: PAS 25 236 Agency: National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Innovative Biospecimen Science Technologies for Basic and Clinical Cancer Research (R61 Clinical Trial Not Allowed) Apply for RFA CA 25 003 Funding Number: RFA CA 25 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
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